FAM50A

Across TCGA pan-cancer cohorts, FAM50A Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated FAM50A data layer compared with 29 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher FAM50A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated FAM50A expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

ESCA and SKCM are the cancer types where FAM50A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	All	0.147	0.700	.002	6	view →
SKCM	DFS	Median	All	1.000	0.199	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

FAM50A–ESCA (OS)

Open the ESCA breakdown →