FAM50A

Across TCGA pan-cancer cohorts, FAM50A mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated FAM50A data layer compared with 29 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher FAM50A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated FAM50A expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

HNSC, CCRCC, and PDAC are the cancer types where FAM50A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.215	0.810	.014	18	view →
CCRCC	DFS	Tertile	IV	0.784	0.138	.024	7	view →
PDAC	OS	Quartile	All	0.326	0.588	.024	3	view →
GBM	DFS	Quartile	All	0.468	0.214	.049	2	view →
LSCC	DFS	Tertile	II,III,IV	1.000	0.438	.040	2	view →
LUAD	OS	Median	III,IV	0.265	1.000	.034	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

FAM50A–HNSC (DFS)

Open the HNSC breakdown →