Across TCGA pan-cancer cohorts, FAM47B Mutation is linked to patient survival in 8 of 34 cancer types, making it the most broadly survival-associated FAM47B data layer compared with 8 for mass-spec protein.
The strongest signal is observed in brain lower grade glioma (LGG), where higher FAM47B Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated FAM47B expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.
LGG, LUAD, and UCEC are the cancer types where FAM47B Mutation most reproducibly stratifies survival.
Mutation survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.