FAM41C

Across TCGA patient cohorts, FAM41C mutation is significantly associated with the RNA expression of many other genes, with 70 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM41C-associated genes across cancer lineages are RNU6-478P, RNU1-17P, and SNORD114-18. Each is linked with FAM41C in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM41C-to-partner and partner-to-FAM41C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-478P grouped by FAM41C-low versus FAM41C-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM41C→partner) and Y-score (partner→FAM41C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-478P →	+0.333	+7.640	<.001	.009	3	1
UCEC	RNU1-17P →	+0.242	+3.198	.006	.009	3	1
UCEC	SNORD114-18 →	+0.743	+4.299	<.001	<.001	3	1
UCEC	RNU6-933P →	+0.604	+2.921	.001	.006	3	1
UCEC	RNU6-649P →	+0.386	+3.505	<.001	.005	3	1
UCEC	MIR517C →	+0.301	+4.137	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 70 associations by consensus.

RNU6-478P by FAM41C expression — BLCA

Explore this box plot interactively →