FAM41C

Across TCGA pan-cancer cohorts, FAM41C RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of FAM41C’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where FAM41C RNA is repressed in tumor relative to normal tissue. In most cancer types FAM41C is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

LUSC, LUAD, and BRCA are the cancer types where FAM41C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM41C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Female	All	−0.300	<.001	8	view →
LUAD	All	III,IV	−0.332	<.001	6	view →
BRCA	Female	II,III,IV	−0.113	<.001	6	view →
KIRP	All	All	+0.166	.010	2	view →
HNSC	All	All	−0.149	.023	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

FAM41C–LUSC

Open the LUSC breakdown →