FAM27E5

Across TCGA patient cohorts, FAM27E5 mutation is significantly associated with the RNA expression of many other genes, with 874 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM27E5-associated genes across cancer lineages are RN7SL299P, MIR548AS, and MIR6793. Each is linked with FAM27E5 in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM27E5-to-partner and partner-to-FAM27E5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL299P grouped by FAM27E5-low versus FAM27E5-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM27E5→partner) and Y-score (partner→FAM27E5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SL299P →	+0.102	+4.469	<.001	.006	3	2
BRCA	MIR548AS →	+0.758	+8.471	<.001	.005	3	2
UCEC	MIR6793 →	+0.655	+2.706	.002	<.001	3	2
CESC	TRAJ21 →	+0.695	+5.345	<.001	.001	3	2
UCEC	RN7SKP264 →	+0.269	+2.936	<.001	<.001	3	2
BRCA	RNA5SP517 →	+0.468	+8.055	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 874 associations by consensus.

RN7SL299P by FAM27E5 expression — SKCM

Explore this box plot interactively →