FAM27B

Across TCGA pan-cancer cohorts, FAM27B RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated FAM27B data layer.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher FAM27B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated FAM27B expression acts as an unfavorable survival marker, although some lineages such as STAD and OV show a favorable association.

LIHC, BRCA, and STAD are the cancer types where FAM27B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Tertile	All	0.051	0.777	<.001	108	view →
BRCA	OS	Tertile	All	0.142	0.580	<.001	72	view →
STAD	OS	Tertile	III,IV	0.799	0.327	.002	46	view →
OV	OS	Tertile	All	0.453	0.299	.006	30	view →
KICH	OS	Tertile	III,IV	0.178	0.847	<.001	18	view →
KIRC	DFS	Tertile	All	0.945	0.614	.026	18	view →
MESO	DFS	Tertile	All	0.098	0.366	.039	18	view →
ACC	DFS	Tertile	II,III,IV	0.242	0.724	.034	18	view →
HNSC	OS	Tertile	All	0.463	0.769	.048	9	view →
BLCA	DFS	Tertile	All	0.703	0.324	.040	6	view →
PAAD	OS	Tertile	All	0.857	0.369	.048	3	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

FAM27B–LIHC (OS)

Open the LIHC breakdown →