FAM25C

Across TCGA patient cohorts, FAM25C mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM25C-associated genes across cancer lineages are RNU6-271P, RNU4-56P, and ARPP19P2. Each is linked with FAM25C in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM25C-to-partner and partner-to-FAM25C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-271P grouped by FAM25C-low versus FAM25C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM25C→partner) and Y-score (partner→FAM25C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-271P →	+0.542	+4.267	<.001	.009	3	1
UCEC	RNU4-56P →	+0.313	+4.997	.006	.003	3	1
UCEC	ARPP19P2 →	+0.309	+4.354	.009	.002	3	1
UCEC	RPL23AP46 →	+0.318	+3.863	<.001	.008	3	1
UCEC	GUSBP17 →	+0.145	+4.750	<.001	.005	3	1
UCEC	CDC27P2 →	+0.052	+4.344	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

RNU6-271P by FAM25C expression — UCEC

Explore this box plot interactively →