FAM25C

Across TCGA pan-cancer cohorts, FAM25C RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of FAM25C’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where FAM25C RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FAM25C is over-expressed in tumor, although a few such as READ show the opposite, repressed pattern.

LUSC and READ are the cancer types where FAM25C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM25C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	All	+0.224	<.001	3	view →
READ	All	All	−0.233	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

FAM25C–LUSC

Open the LUSC breakdown →