Across TCGA pan-cancer cohorts, FAM242A RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of FAM242A’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where FAM242A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FAM242A is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.
KIRP and KIRC are the cancer types where FAM242A tumor–normal differential expression is most reproducible.