Across TCGA patient cohorts, FAM228B mutation is significantly associated with the RNA expression of many other genes, with 1,115 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM228B-associated genes across cancer lineages are FADS1, CPSF7, and PLCB3. Each is linked with FAM228B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM228B-to-partner and partner-to-FAM228B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM228B→partner) and Y-score (partner→FAM228B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FADS1 →	+1.060	+3.475	<.001	.002	3	1
UCEC	CPSF7 →	+0.454	+3.337	.003	.005	3	1
UCEC	PLCB3 →	+0.483	+3.346	.007	.005	3	1
UCEC	SRFBP1 →	+0.631	+2.595	.008	.006	3	1
UCEC	FAM177A1 →	+0.501	+3.711	<.001	<.001	3	1
UCEC	VTI1A →	+0.462	+3.354	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,115 associations by consensus.

Exploration

FAM228B survival (RNA) · tumor vs normal (RNA) · all FAM228B data types