Across TCGA pan-cancer cohorts, FAM228B RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of FAM228B’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where FAM228B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FAM228B is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.
KIRC, THCA, and KICH are the cancer types where FAM228B tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM228B RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.