Across TCGA patient cohorts, FAM228B mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM228B-associated genes across cancer lineages are ERK2, ACC1, and JNK_pT183_Y185. Each is linked with FAM228B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM228B-to-partner and partner-to-FAM228B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM228B→partner) and Y-score (partner→FAM228B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.205	+2.321	.034	.035	3	1
UCEC	ACC1 →	+0.401	+2.321	.028	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.185	-3.446	.028	.005	3	1
UCEC	p90 RSK_pT359_S363 →	-0.237	-2.990	.020	.036	3	1
UCEC	PDCD4 →	-0.652	-3.312	.005	.010	3	1
UCEC	RBM15 →	+0.384	+3.321	.016	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Exploration

FAM228B survival (RNA) · tumor vs normal (RNA) · all FAM228B data types