FAM227B

Across TCGA patient cohorts, FAM227B RNA expression is significantly associated with the protein abundance of many other proteins, with 14,585 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible FAM227B-associated proteins across cancer lineages are TP53BP1, ITGAM, and MPI. Each is linked with FAM227B in more than 6 cancer types. Because this analysis shows association rather than direction, both FAM227B-to-partner and partner-to-FAM227B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FAM227B versus TP53BP1 in OV, with a Pearson correlation of 0.39.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM227B→partner) and Y-score (partner→FAM227B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TP53BP1 →	+0.357	+0.595	<.001	<.001	3	7
GBM	ITGAM →	-0.692	-0.340	.002	.003	3	5
BRCA	MPI →	+0.461	+0.576	<.001	<.001	3	5
LSCC	MYEF2 →	+0.826	+0.434	.001	<.001	3	5
HNSC	MYEF2_S17 →	+0.819	+0.366	.001	.006	3	5
PDAC	RING1 →	+0.313	+0.273	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,585 associations by consensus.

FAM227B vs TP53BP1 — OV

Explore this scatter interactively →