FAM227B

Across TCGA patient cohorts, FAM227B mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM227B-associated genes across cancer lineages are ATM, Bcl-2, and Caspase-7-cleavedD198. Each is linked with FAM227B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM227B-to-partner and partner-to-FAM227B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by FAM227B-low versus FAM227B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM227B→partner) and Y-score (partner→FAM227B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.550	-3.794	<.001	<.001	3	2
SKCM	Bcl-2 →	-0.367	-3.169	.040	.018	3	2
UCEC	Caspase-7-cleavedD198 →	+0.738	+3.019	<.001	<.001	3	2
SKCM	ACC_pS79 →	+0.353	+3.000	.014	.035	3	2
UCEC	14-3-3_beta →	-0.096	-2.780	.004	.003	3	1
UCEC	EGFR_pY1068 →	-0.249	-1.514	.003	.015	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

ATM by FAM227B expression — UCEC

Explore this box plot interactively →