FAM224B

Across TCGA pan-cancer cohorts, FAM224B RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated FAM224B data layer.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher FAM224B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated FAM224B expression acts as an unfavorable survival marker, although some lineages such as HNSC and THCA show a favorable association.

UCEC, KIRP, and UVM are the cancer types where FAM224B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	III,IV	0.069	0.597	<.001	72	view →
KIRP	DFS	Tertile	II,III,IV	0.456	0.739	.004	55	view →
UVM	DFS	Tertile	III,IV	0.107	0.677	.004	45	view →
COAD	OS	Tertile	IV	0.140	0.711	<.001	42	view →
KIRC	OS	Quartile	II,III,IV	0.371	0.626	.003	39	view →
ESCA	OS	Tertile	All	0.198	0.872	.003	36	view →
HNSC	OS	Tertile	IV	0.474	0.323	.020	31	view →
THCA	DFS	Tertile	All	1.000	0.815	.014	21	view →
SKCM	DFS	Tertile	III,IV	0.206	0.659	.006	18	view →
READ	OS	Tertile	All	0.810	0.921	.015	18	view →
DLBC	DFS	Tertile	III,IV	0.137	0.761	.014	9	view →
LUSC	DFS	Median	All	0.696	0.594	.017	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

FAM224B–UCEC (OS)

Open the UCEC breakdown →