FAM224B

Across TCGA pan-cancer cohorts, FAM224B RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of FAM224B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where FAM224B RNA is repressed in tumor relative to normal tissue. In most cancer types FAM224B is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and BRCA are the cancer types where FAM224B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM224B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	−0.038	<.001	7	view →
KIRP	Male	All	−0.092	.003	2	view →
BRCA	All	III,IV	+0.005	.043	2	view →
THCA	Female	All	+0.004	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

FAM224B–KIRC

Open the KIRC breakdown →