FAM224A

Across TCGA pan-cancer cohorts, FAM224A RNA is linked to patient survival in 12 of 34 cancer types, making it the most broadly survival-associated FAM224A data layer.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher FAM224A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated FAM224A expression acts as an unfavorable survival marker, although some lineages such as LAML and GBM show a favorable association.

UCEC, ACC, and LIHC are the cancer types where FAM224A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	III,IV	0.053	0.576	.002	78	view →
ACC	DFS	Tertile	All	0.046	0.753	<.001	72	view →
LIHC	OS	Tertile	II,III,IV	0.092	0.716	<.001	63	view →
PAAD	DFS	Tertile	All	0.098	0.505	.002	36	view →
LAML	DFS	Tertile	All	0.756	0.312	.006	36	view →
BLCA	OS	Tertile	All	0.182	0.592	.034	27	view →
READ	OS	Tertile	IV	0.111	0.893	<.001	27	view →
CHOL	OS	Tertile	All	0.201	0.740	.003	18	view →
THYM	DFS	Tertile	II,III,IV	0.172	0.747	.005	18	view →
GBM	DFS	Tertile	All	0.306	0.178	.021	15	view →
HNSC	DFS	Tertile	II,III,IV	0.463	0.701	.032	9	view →
ESCA	OS	Quartile	All	0.404	0.546	.048	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

FAM224A–UCEC (DFS)

Open the UCEC breakdown →