FAM224A

Across TCGA pan-cancer cohorts, FAM224A RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of FAM224A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where FAM224A RNA is repressed in tumor relative to normal tissue. In most cancer types FAM224A is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and BRCA are the cancer types where FAM224A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM224A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	All	−0.009	.009	2	view →
THCA	All	All	−0.006	.010	2	view →
BRCA	All	II,III,IV	+0.004	.032	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

FAM224A–KICH

Open the KICH breakdown →