FAM222A

Across TCGA patient cohorts, FAM222A RNA expression is significantly associated with the protein abundance of many other proteins, with 22,831 significant associations in total. GBM shows the largest number of these associations.

The most reproducible FAM222A-associated proteins across cancer lineages are CUL4B, LRRFIP1, and NFKB1. Each is linked with FAM222A in more than 4 cancer types. Because this analysis shows association rather than direction, both FAM222A-to-partner and partner-to-FAM222A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FAM222A versus CUL4B in HNSC, with a Pearson correlation of 0.33.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM222A→partner) and Y-score (partner→FAM222A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CUL4B →	+0.288	+0.942	<.001	<.001	3	5
LSCC	LRRFIP1 →	-0.303	-0.719	<.001	<.001	3	5
GBM	NFKB1 →	-0.266	-1.077	<.001	<.001	3	5
GBM	ZYX →	-0.459	-1.285	<.001	<.001	3	4
GBM	ZYX_S143 →	-0.663	-0.754	<.001	.005	3	4
GBM	ZYX_S267 →	-0.587	-1.112	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 22,831 associations by consensus.

FAM222A vs CUL4B — HNSC

Explore this scatter interactively →