FAM222A

Across TCGA patient cohorts, FAM222A mutation is significantly associated with the RNA expression of many other genes, with 605 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM222A-associated genes across cancer lineages are IGHVII-30-1, RAB28P3, and TRAJ25. Each is linked with FAM222A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM222A-to-partner and partner-to-FAM222A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGHVII-30-1 grouped by FAM222A-low versus FAM222A-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM222A→partner) and Y-score (partner→FAM222A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	IGHVII-30-1 →	+0.189	+5.588	<.001	.004	3	2
BLCA	RAB28P3 →	+0.199	+5.685	<.001	.003	3	2
COAD	TRAJ25 →	+0.551	+5.003	<.001	.004	3	2
COAD	RNY1P15 →	+0.748	+4.717	.004	.003	3	2
COAD	RN7SL408P →	+0.631	+4.266	.009	.008	3	2
BLCA	NMS →	+0.278	+6.289	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 605 associations by consensus.

IGHVII-30-1 by FAM222A expression — BLCA

Explore this box plot interactively →