FAM222A

Across TCGA patient cohorts, FAM222A mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM222A-associated genes across cancer lineages are Ku80, Notch1, and PCNA. Each is linked with FAM222A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM222A-to-partner and partner-to-FAM222A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by FAM222A-low versus FAM222A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM222A→partner) and Y-score (partner→FAM222A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.266	+3.009	.025	.019	3	1
UCEC	Notch1 →	+0.225	+2.321	.001	.035	3	1
UCEC	PCNA →	+0.267	+2.321	.014	.035	3	1
UCEC	VHL →	-0.823	-2.321	.015	.035	3	1
UCEC	Caspase-7-cleavedD198 →	+0.860	+2.321	.003	.035	1	2
UCEC	Caspase-8 →	-0.289	-3.321	.022	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Ku80 by FAM222A expression — UCEC

Explore this box plot interactively →