FAM222A

Across TCGA cell cohorts, FAM222A mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FAM222A-associated genes across cancer lineages are ADAM7, RBMY1J, and NKX2-6. Each is linked with FAM222A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM222A-to-partner and partner-to-FAM222A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAM7 grouped by FAM222A-low versus FAM222A-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM222A→partner) and Y-score (partner→FAM222A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ADAM7 →	+0.063	+5.285	<.001	.003	3	1
SKIN	RBMY1J →	+0.006	+4.977	<.001	.007	3	1
BLOOD_Leukemia	NKX2-6 →	+0.591	+5.201	<.001	.006	3	1
BLOOD_Leukemia	TLE7 →	+0.042	+5.969	<.001	.001	3	1
LARGE_INTESTINE	C10orf53 →	+0.024	+5.217	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

ADAM7 by FAM222A expression — STOMACH

Explore this box plot interactively →