FAM222A-AS1

Across TCGA pan-cancer cohorts, FAM222A-AS1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated FAM222A-AS1 data layer.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher FAM222A-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated FAM222A-AS1 expression acts as an unfavorable survival marker, although some lineages such as LGG and KIRC show a favorable association.

UCEC, LGG, and KICH are the cancer types where FAM222A-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	All	0.877	0.946	<.001	78	view →
LGG	DFS	Median	All	0.807	0.667	<.001	43	view →
KICH	OS	Median	All	0.747	0.970	.006	20	view →
TGCT	DFS	Quartile	II,III,IV	0.586	0.996	.018	20	view →
LIHC	OS	Tertile	All	0.347	0.557	.006	20	view →
UVM	DFS	Quartile	III,IV	0.241	1.000	.006	16	view →
OV	OS	Median	IV	0.602	0.868	<.001	16	view →
SKCM	OS	Median	All	0.739	0.828	.010	12	view →
CHOL	DFS	Quartile	II,III,IV	0.185	0.592	.010	12	view →
KIRC	DFS	Median	All	0.717	0.506	.010	9	view →
MESO	DFS	Quartile	III,IV	0.108	0.667	.010	9	view →
ACC	OS	Tertile	II,III,IV	0.386	0.809	.017	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

FAM222A-AS1–UCEC (OS)

Open the UCEC breakdown →