FAM222A-AS1

Across TCGA pan-cancer cohorts, FAM222A-AS1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of FAM222A-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where FAM222A-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FAM222A-AS1 is over-expressed in tumor, although a few such as KIRC and BRCA show the opposite, repressed pattern.

COAD, LUAD, and KIRC are the cancer types where FAM222A-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM222A-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	+1.822	<.001	11	view →
LUAD	Male	II,III,IV	+0.904	<.001	8	view →
KIRC	Male	All	−0.564	<.001	7	view →
BRCA	Female	II,III,IV	−0.473	<.001	6	view →
BLCA	All	All	+0.387	.001	6	view →
LUSC	Male	All	+0.662	<.001	5	view →
KICH	All	All	−0.610	<.001	4	view →
STAD	All	All	+0.455	.004	4	view →
READ	All	All	+1.252	.010	2	view →
PRAD	All	All	+1.016	<.001	2	view →
CHOL	All	All	−0.602	.002	2	view →
KIRP	Male	All	−0.532	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

FAM222A-AS1–COAD

Open the COAD breakdown →