Across TCGA patient cohorts, FAM221B mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM221B-associated genes across cancer lineages are 14-3-3_beta, Myosin-IIa, and p53. Each is linked with FAM221B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM221B-to-partner and partner-to-FAM221B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM221B→partner) and Y-score (partner→FAM221B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.129	-2.446	.008	.020	3	1
UCEC	Myosin-IIa →	+0.207	+2.466	.020	.011	3	1
UCEC	p53 →	-0.368	-3.000	.049	.036	3	1
UCEC	S6_pS240_S244 →	+0.434	+2.459	.027	.020	3	1
UCEC	Cyclin-B1 →	+0.574	+3.000	.034	.036	3	1
SKCM	MEK1 →	-0.525	-3.000	.009	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

FAM221B survival (RNA) · tumor vs normal (RNA) · all FAM221B data types