Across TCGA cell cohorts, FAM221B RNA expression is significantly associated with the go_rna of many other GO terms, with 2,682 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible FAM221B-associated GO terms across cancer lineages are Positive regulation of intracellular estrogen receptor signaling pathway, Positive regulation of intracellular steroid hormone receptor signaling pathway, and Flagellated sperm motility. Each is linked with FAM221B in more than 9 cancer types. Because this analysis shows association rather than direction, both FAM221B-to-partner and partner-to-FAM221B results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM221B→partner) and Y-score (partner→FAM221B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Positive regulation of intracellular estrogen receptor signaling pathway →	+0.192	+0.067	<.001	.004	3	10
LUNG_SCLC	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.176	+0.080	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Flagellated sperm motility →	-0.134	-0.110	<.001	.005	3	9
BREAST	Macroautophagy →	+0.039	+0.211	.001	.006	3	9
UPPER_AERODIGESTIVE_TRACT	Sperm motility →	-0.134	-0.110	<.001	.005	3	9
UPPER_AERODIGESTIVE_TRACT	Cilium or flagellum-dependent cell motility →	-0.127	-0.114	<.001	.003	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,682 associations by consensus.

Exploration

FAM221B survival (RNA) · tumor vs normal (RNA) · all FAM221B data types