Across TCGA cell cohorts, FAM221B mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible FAM221B-associated genes across cancer lineages are SLC10A2, MMP26, and TPPP2. Each is linked with FAM221B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM221B-to-partner and partner-to-FAM221B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM221B→partner) and Y-score (partner→FAM221B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SLC10A2 →	+0.005	+5.022	<.001	.002	3	1
SKIN	MMP26 →	+0.020	+5.022	<.001	.002	3	1
SKIN	TPPP2 →	+0.077	+5.217	<.001	<.001	3	1
SKIN	TCP11X2 →	+0.019	+4.684	<.001	.002	3	1
BREAST	OR2M3 →	+0.006	+5.169	<.001	.005	3	1
LARGE_INTESTINE	CFHR2 →	+0.057	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

FAM221B survival (RNA) · tumor vs normal (RNA) · all FAM221B data types