FAM21FP

Across TCGA pan-cancer cohorts, FAM21FP RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated FAM21FP data layer compared with 2 for mutation status.

The strongest signal is observed in kidney chromophobe (KICH), where higher FAM21FP RNA is associated with worse overall survival. In most high-consensus cancer types, elevated FAM21FP expression acts as an unfavorable survival marker, although some lineages such as LUAD and THYM show a favorable association.

KICH, LUAD, and THYM are the cancer types where FAM21FP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Median	III,IV	0.759	1.000	.004	49	view →
LUAD	OS	Median	All	0.426	0.304	.001	37	view →
THYM	DFS	Median	II,III,IV	0.946	0.486	.004	26	view →
KIRC	DFS	Tertile	II,III,IV	0.403	0.622	.002	23	view →
PAAD	OS	Median	All	0.653	0.308	.001	23	view →
UCS	OS	Quartile	II,III,IV	0.681	0.237	.018	22	view →
UVM	OS	Median	III,IV	0.281	1.000	.003	21	view →
LGG	OS	Tertile	All	0.948	0.824	<.001	21	view →
ACC	DFS	Median	IV	0.570	0.087	.003	21	view →
LIHC	DFS	Tertile	All	0.456	0.601	.004	19	view →
BLCA	OS	Quartile	IV	0.271	0.688	.006	12	view →
STAD	DFS	Median	IV	0.152	0.503	.006	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

FAM21FP–KICH (OS)

Open the KICH breakdown →