FAM21FP

Across TCGA pan-cancer cohorts, FAM21FP RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of FAM21FP’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where FAM21FP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FAM21FP is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

LIHC, KICH, and KIRP are the cancer types where FAM21FP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM21FP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	All	II,III,IV	+0.335	<.001	8	view →
KICH	Male	All	−0.633	<.001	6	view →
KIRP	All	II,III,IV	+0.410	<.001	6	view →
CHOL	All	All	+0.616	<.001	4	view →
COAD	Female	III,IV	−0.335	.008	4	view →
BRCA	All	All	−0.174	<.001	4	view →
KIRC	All	All	+0.133	.004	4	view →
PRAD	All	All	+0.320	<.001	2	view →
ESCA	All	II,III,IV	+0.195	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

FAM21FP–LIHC

Open the LIHC breakdown →