FAM219B

Across TCGA patient cohorts, FAM219B mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible FAM219B-associated genes across cancer lineages are MIR6853, DEFB108E, and MIR548AD. Each is linked with FAM219B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM219B-to-partner and partner-to-FAM219B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6853 grouped by FAM219B-low versus FAM219B-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM219B→partner) and Y-score (partner→FAM219B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR6853 →	+0.364	+9.057	<.001	.003	3	1
BRCA	DEFB108E →	+0.108	+8.055	<.001	.007	3	1
BRCA	MIR548AD →	+0.338	+8.471	<.001	.005	3	1
BLCA	KRTAP12-6P →	+0.189	+7.640	<.001	.009	3	1
BRCA	RNU7-82P →	+0.415	+7.731	<.001	.009	3	1
BRCA	RNA5SP446 →	+0.286	+8.471	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

MIR6853 by FAM219B expression — BRCA

Explore this box plot interactively →