FAM219A

Across TCGA patient cohorts, FAM219A mutation is significantly associated with the RNA expression of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM219A-associated genes across cancer lineages are DEFB104B, RNU4ATAC7P, and RGPD5. Each is linked with FAM219A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM219A-to-partner and partner-to-FAM219A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB104B grouped by FAM219A-low versus FAM219A-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM219A→partner) and Y-score (partner→FAM219A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DEFB104B →	+0.099	+9.057	<.001	.003	3	2
BRCA	RNU4ATAC7P →	+0.278	+8.055	<.001	.007	3	1
UCEC	RGPD5 →	+0.009	+3.442	.001	.001	3	1
UCEC	SSTR5 →	+0.805	+2.871	<.001	.008	3	1
UCEC	KIR3DL1 →	+0.262	+3.495	.002	.008	3	1
UCEC	PMS2P6 →	+0.402	+3.304	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

DEFB104B by FAM219A expression — BRCA

Explore this box plot interactively →