Across TCGA pan-cancer cohorts, FAM218BP RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of FAM218BP’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where FAM218BP RNA is repressed in tumor relative to normal tissue. In most cancer types FAM218BP is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.
COAD are the cancer types where FAM218BP tumor–normal differential expression is most reproducible.