FAM218A

Across TCGA patient cohorts, FAM218A mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM218A-associated genes across cancer lineages are eEF2, EGFR_pY1068, and A-Raf_pS299. Each is linked with FAM218A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM218A-to-partner and partner-to-FAM218A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by FAM218A-low versus FAM218A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM218A→partner) and Y-score (partner→FAM218A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.283	+1.678	.039	.023	3	1
UCEC	EGFR_pY1068 →	-0.267	-2.115	.005	.017	3	1
UCEC	A-Raf_pS299 →	-0.154	-2.700	<.001	.006	3	1
UCEC	JNK_pT183_Y185 →	-0.135	-1.700	.036	.042	3	1
UCEC	JNK2 →	+0.305	+2.331	<.001	.003	3	1
UCEC	Ku80 →	+0.259	+2.232	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

eEF2 by FAM218A expression — UCEC

Explore this box plot interactively →