Across TCGA patient cohorts, FAM217B mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM217B-associated genes across cancer lineages are MEK1, 14-3-3_beta, and EGFR_pY1068. Each is linked with FAM217B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM217B-to-partner and partner-to-FAM217B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM217B→partner) and Y-score (partner→FAM217B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.380	+2.584	.009	.010	3	2
UCEC	14-3-3_beta →	-0.094	-2.973	.019	.035	3	1
UCEC	EGFR_pY1068 →	-0.282	-2.415	.005	.003	3	1
UCEC	A-Raf_pS299 →	-0.157	-3.169	.001	.018	3	1
UCEC	INPP4B →	-0.291	-1.893	.025	.016	3	1
UCEC	JNK_pT183_Y185 →	-0.188	-2.000	.005	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Exploration

FAM217B survival (RNA) · tumor vs normal (RNA) · all FAM217B data types