FAM217A

Across TCGA patient cohorts, FAM217A mutation is significantly associated with the RNA expression of many other genes, with 2,186 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM217A-associated genes across cancer lineages are RNA5SP176, PWWP3A, and AZI2. Each is linked with FAM217A in more than 2 cancer types. Because this analysis shows association rather than direction, both FAM217A-to-partner and partner-to-FAM217A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP176 grouped by FAM217A-low versus FAM217A-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM217A→partner) and Y-score (partner→FAM217A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNA5SP176 →	+0.323	+7.954	<.001	.008	3	3
UCEC	PWWP3A →	+0.373	+2.010	.008	.001	3	2
UCEC	AZI2 →	+0.493	+2.700	<.001	.005	3	2
UCEC	SAP30 →	+0.548	+2.413	.001	<.001	3	2
UCEC	DAGLB →	+0.251	+2.024	.009	.005	3	2
UCEC	FBXO33 →	+0.386	+2.321	.005	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,186 associations by consensus.

RNA5SP176 by FAM217A expression — HNSC

Explore this box plot interactively →