FAM217A

Across TCGA pan-cancer cohorts, FAM217A RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated FAM217A data layer compared with 2 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher FAM217A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated FAM217A expression acts as an unfavorable survival marker, although some lineages such as LAML and BRCA show a favorable association.

UVM, KIRP, and LAML are the cancer types where FAM217A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.570	0.882	<.001	102	view →
KIRP	DFS	Quartile	III,IV	0.223	0.658	.010	55	view →
LAML	DFS	Median	All	0.524	0.235	<.001	30	view →
DLBC	DFS	Tertile	All	0.517	0.955	<.001	24	view →
CHOL	OS	Median	III,IV	0.286	1.000	.008	21	view →
BRCA	DFS	Median	III,IV	0.849	0.735	.008	18	view →
LIHC	DFS	Quartile	All	0.412	0.617	.002	12	view →
THCA	OS	Quartile	All	0.913	0.992	.016	12	view →
SKCM	OS	Median	IV	0.140	0.621	.044	9	view →
ACC	DFS	Quartile	IV	0.111	0.521	.024	8	view →
SARC	OS	Quartile	All	0.778	0.940	.002	5	view →
STAD	DFS	Quartile	II,III,IV	0.319	0.544	.037	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

FAM217A–UVM (DFS)

Open the UVM breakdown →