FAM217A

Across TCGA patient cohorts, FAM217A mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM217A-associated genes across cancer lineages are ATM, mTOR_pS2448, and ASNS. Each is linked with FAM217A in more than 2 cancer types. Because this analysis shows association rather than direction, both FAM217A-to-partner and partner-to-FAM217A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by FAM217A-low versus FAM217A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM217A→partner) and Y-score (partner→FAM217A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.620	-2.807	<.001	.003	3	3
UCEC	mTOR_pS2448 →	-0.141	-2.308	.013	.033	3	2
UCEC	ASNS →	+0.535	+1.906	<.001	.015	3	2
UCEC	EGFR_pY1068 →	-0.215	-4.321	.025	<.001	3	1
UCEC	eIF4E →	+0.186	+2.584	.021	.001	3	1
UCEC	A-Raf_pS299 →	-0.126	-1.678	.006	.023	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

ATM by FAM217A expression — UCEC

Explore this box plot interactively →