FAM214A

Across TCGA pan-cancer cohorts, FAM214A Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated FAM214A data layer compared with 27 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher FAM214A Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated FAM214A expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, HNSC, and LUAD are the cancer types where FAM214A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	1.000	0.618	.004	36	view →
HNSC	DFS	Median	All	0.134	0.712	<.001	36	view →
LUAD	OS	Median	All	0.719	0.835	.007	19	view →
BLCA	OS	Median	III,IV	0.051	0.684	<.001	18	view →
SKCM	OS	Median	III,IV	0.342	0.744	.004	9	view →
BRCA	DFS	Median	All	0.119	0.527	<.001	8	view →
STAD	OS	Median	All	0.197	0.568	.037	6	view →
LIHC	DFS	Median	II,III,IV	0.044	0.427	<.001	6	view →
READ	OS	Median	All	0.281	0.830	.031	3	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →
COAD	OS	Median	All	0.224	0.684	.011	2	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

FAM214A–UCEC (DFS)

Open the UCEC breakdown →