FAM214A

Across TCGA patient cohorts, FAM214A mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM214A-associated genes across cancer lineages are PCNA, ATM, and EGFR_pY1068. Each is linked with FAM214A in more than 2 cancer types. Because this analysis shows association rather than direction, both FAM214A-to-partner and partner-to-FAM214A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by FAM214A-low versus FAM214A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM214A→partner) and Y-score (partner→FAM214A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.186	+2.807	.011	.003	3	3
UCEC	ATM →	-0.461	-2.321	.002	.005	3	3
UCEC	EGFR_pY1068 →	-0.222	-2.137	.009	.001	3	2
UCEC	FASN →	+0.280	+1.906	.037	.015	3	2
UCEC	JNK2 →	+0.139	+1.514	.040	.015	3	2
UCEC	PDCD4 →	-0.469	-2.115	.003	.016	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

PCNA by FAM214A expression — UCEC

Explore this box plot interactively →