FAM214A

Across TCGA cell cohorts, FAM214A mutation is significantly associated with the RNA expression of many other genes, with 31 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FAM214A-associated genes across cancer lineages are ZNF804B, SLC6A18, and MS4A3. Each is linked with FAM214A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM214A-to-partner and partner-to-FAM214A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF804B grouped by FAM214A-low versus FAM214A-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM214A→partner) and Y-score (partner→FAM214A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ZNF804B →	+0.019	+4.350	<.001	.005	3	2
UPPER_AERODIGESTIVE_TRACT	SLC6A18 →	+0.017	+4.209	.002	.006	3	1
LARGE_INTESTINE	MS4A3 →	+0.075	+3.584	.001	.003	3	1
LARGE_INTESTINE	KCND3 →	+0.344	+2.770	<.001	.004	3	1
LARGE_INTESTINE	XKR3 →	+0.024	+2.793	.009	.002	3	1
LARGE_INTESTINE	RAX2 →	+0.053	+2.518	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

ZNF804B by FAM214A expression — BLOOD_Lymphoma

Explore this box plot interactively →