FAM205BP

Across TCGA patient cohorts, FAM205BP mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM205BP-associated genes across cancer lineages are EGFR_pY1068, Notch1, and Shc_pY317. Each is linked with FAM205BP in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM205BP-to-partner and partner-to-FAM205BP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by FAM205BP-low versus FAM205BP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM205BP→partner) and Y-score (partner→FAM205BP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.372	-4.523	<.001	<.001	3	2
UCEC	Notch1 →	+0.176	+2.817	<.001	.001	3	2
UCEC	Shc_pY317 →	-0.254	-2.999	<.001	<.001	3	2
UCEC	ATM →	-0.547	-1.584	<.001	.019	3	2
UCEC	C-Raf →	+0.172	+1.584	<.001	.019	3	2
UCEC	eEF2 →	+0.398	+2.321	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

EGFR_pY1068 by FAM205BP expression — UCEC

Explore this box plot interactively →