FAM199X

Across TCGA patient cohorts, FAM199X mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM199X-associated genes across cancer lineages are EGFR_pY1068, EGFR_pY1173, and eIF4E. Each is linked with FAM199X in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM199X-to-partner and partner-to-FAM199X results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by FAM199X-low versus FAM199X-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM199X→partner) and Y-score (partner→FAM199X) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.223	-2.115	.042	.019	3	1
UCEC	EGFR_pY1173 →	-0.096	-2.301	.006	.034	3	1
UCEC	eIF4E →	+0.254	+3.013	.005	.018	3	1
UCEC	Annexin-1 →	+0.660	+2.807	.004	.003	3	1
UCEC	Smad3 →	-0.164	-2.999	.012	.035	3	1
UCEC	Tuberin_pT1462 →	+0.258	+2.115	.010	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

EGFR_pY1068 by FAM199X expression — UCEC

Explore this box plot interactively →