FAM199X

Across TCGA pan-cancer cohorts, FAM199X RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of FAM199X’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where FAM199X RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FAM199X is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

BLCA, HNSC, and LIHC are the cancer types where FAM199X tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM199X RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	III,IV	+0.694	<.001	12	view →
HNSC	All	III,IV	+0.849	<.001	11	view →
LIHC	Male	II,III,IV	+1.113	<.001	9	view →
STAD	All	II,III,IV	+0.961	<.001	8	view →
THCA	Male	All	−0.662	<.001	8	view →
KIRP	All	II,III,IV	+0.653	.001	8	view →
KIRC	All	All	−0.299	<.001	7	view →
LUAD	Male	All	+0.645	<.001	6	view →
CHOL	Male	All	+1.906	<.001	5	view →
COAD	Male	All	+0.549	.002	5	view →
LUSC	Male	All	+0.366	.001	4	view →
BRCA	All	II,III,IV	+0.257	.002	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

FAM199X–BLCA

Open the BLCA breakdown →