FAM193A

Across TCGA patient cohorts, FAM193A mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM193A-associated genes across cancer lineages are 4E-BP1, STAT3_pY705, and TSC1. Each is linked with FAM193A in more than 2 cancer types. Because this analysis shows association rather than direction, both FAM193A-to-partner and partner-to-FAM193A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by FAM193A-low versus FAM193A-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM193A→partner) and Y-score (partner→FAM193A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	4E-BP1 →	+0.350	+3.000	.001	.035	3	3
UCEC	STAT3_pY705 →	-0.313	-1.838	<.001	.007	3	3
COAD	TSC1 →	-0.571	-3.161	<.001	.019	3	2
UCEC	Notch1 →	+0.174	+2.335	<.001	.002	3	2
UCEC	PCNA →	+0.195	+1.584	.006	.017	3	2
UCEC	ATM →	-0.550	-1.938	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

4E-BP1 by FAM193A expression — COAD

Explore this box plot interactively →