FAM193A

Across TCGA pan-cancer cohorts, FAM193A RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated FAM193A data layer compared with 5 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher FAM193A RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated FAM193A expression acts as an unfavorable survival marker, although some lineages such as UCS and HNSC show a favorable association.

UCS, ACC, and LIHC are the cancer types where FAM193A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Median	III,IV	0.656	0.217	<.001	92	view →
ACC	DFS	Quartile	All	0.322	0.852	.001	54	view →
LIHC	OS	Quartile	II,III,IV	0.394	0.684	.003	48	view →
KICH	DFS	Quartile	III,IV	0.037	1.000	.004	47	view →
HNSC	DFS	Median	IV	0.666	0.484	.002	47	view →
UCEC	DFS	Median	III,IV	0.865	0.719	.008	44	view →
UVM	DFS	Quartile	II,III,IV	0.249	0.658	.004	41	view →
BRCA	OS	Tertile	III,IV	0.914	0.733	<.001	37	view →
PAAD	OS	Quartile	All	0.613	0.236	<.001	33	view →
ESCA	DFS	Median	IV	0.205	0.634	.006	24	view →
KIRC	OS	Tertile	All	0.728	0.580	.008	23	view →
LUSC	OS	Median	IV	0.255	0.851	.021	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

FAM193A–UCS (DFS)

Open the UCS breakdown →