FAM187B

Across TCGA patient cohorts, FAM187B mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM187B-associated genes across cancer lineages are VEGFR2, Ku80, and Notch1. Each is linked with FAM187B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM187B-to-partner and partner-to-FAM187B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VEGFR2 grouped by FAM187B-low versus FAM187B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM187B→partner) and Y-score (partner→FAM187B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VEGFR2 →	+0.310	+3.820	.021	<.001	3	2
UCEC	Ku80 →	+0.295	+3.331	.005	.005	3	1
UCEC	Notch1 →	+0.199	+2.183	.001	.033	3	1
UCEC	Rad50 →	-0.221	-2.000	.043	.032	3	1
UCEC	TFRC →	+0.915	+2.700	<.001	.006	3	1
UCEC	Tuberin →	+0.396	+2.469	.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

VEGFR2 by FAM187B expression — UCEC

Explore this box plot interactively →