FAM187B

Across TCGA pan-cancer cohorts, FAM187B RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated FAM187B data layer compared with 1 for mutation status.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher FAM187B RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated FAM187B expression acts as an unfavorable survival marker, although some lineages such as CESC and BLCA show a favorable association.

CESC, LUSC, and BLCA are the cancer types where FAM187B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Tertile	III,IV	0.879	0.409	<.001	88	view →
LUSC	OS	Tertile	IV	0.001	0.673	.014	43	view →
BLCA	DFS	Median	II,III,IV	0.666	0.564	.016	38	view →
LUAD	OS	Median	All	0.773	0.559	<.001	37	view →
KIRC	DFS	Quartile	II,III,IV	0.374	0.599	.002	33	view →
ACC	DFS	Median	III,IV	0.826	0.290	.001	23	view →
HNSC	OS	Tertile	III,IV	0.528	0.313	.004	22	view →
SARC	OS	Median	All	0.588	0.431	.004	17	view →
THCA	DFS	Median	III,IV	0.903	0.600	.019	13	view →
CHOL	OS	Median	IV	0.208	0.948	.010	12	view →
ESCA	DFS	Quartile	II,III,IV	0.432	0.204	.021	11	view →
LGG	OS	Quartile	All	0.803	0.911	.005	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

FAM187B–CESC (DFS)

Open the CESC breakdown →