Across TCGA patient cohorts, FAM186A mutation is significantly associated with the RNA expression of many other genes, with 3,538 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM186A-associated genes across cancer lineages are TRAJ47, GDE1, and TRDV3. Each is linked with FAM186A in more than 2 cancer types. Because this analysis shows association rather than direction, both FAM186A-to-partner and partner-to-FAM186A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM186A→partner) and Y-score (partner→FAM186A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	TRAJ47 →	+0.451	+4.099	<.001	<.001	3	3
UCEC	GDE1 →	+0.393	+2.091	<.001	<.001	3	3
UCEC	TRDV3 →	+0.202	+1.246	<.001	.003	3	3
UCEC	COX7A2 →	+0.290	+1.695	.001	.002	3	3
UCEC	SLC17A5 →	+0.433	+1.959	.001	<.001	3	3
UCEC	ARNTL →	+0.258	+1.786	.006	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,538 associations by consensus.

Exploration

FAM186A survival (RNA) · tumor vs normal (RNA) · all FAM186A data types