FAM186A

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, FAM186A mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM186A-associated genes across cancer lineages are 14-3-3_beta, eEF2, and ERK2. Each is linked with FAM186A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM186A-to-partner and partner-to-FAM186A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM186A→partner) and Y-score (partner→FAM186A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCEC14-3-3_beta →-0.085-2.295.004.00532
UCECeEF2 →+0.226+1.700.034.04032
UCECERK2 →+0.188+1.807.001<.00132
UCECHeregulin →-0.122-1.986<.001.00832
UCECJNK2 →+0.266+2.632<.001<.00132
UCECMEK1 →+0.374+2.201<.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

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